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Antimicrobial Agents and Chemotherapy, March 2005, p. 1206-1208, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1206-1208.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Deletion of the Multiple-Drug Efflux Pump AcrAB in Escherichia coli Prolongs the Postantibiotic Effect

William Stubbings,1 Julieanne Bostock,1 Eileen Ingham,1 and Ian Chopra1*

Antimicrobial Research Centre and School of Biochemistry and Microbiology, University of Leeds, Leeds, United Kingdom1

Received 30 June 2004/ Returned for modification 19 September 2004/ Accepted 30 October 2004

The mechanism of the postantibiotic effect (PAE) was examined in Escherichia coli. Drugs exhibited longer-lasting PAEs in an acrAB mutant, suggesting that intracellular drug concentrations influence the duration of the PAE. With specific assays for tetracycline and erythromycin, a direct link between intracellular persistence of antibiotics and maintenance of the PAE was established.

* Corresponding author. Mailing address: Antimicrobial Research Centre and School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom. Phone: 44 113 343 5604. Fax: 44 113 343 5638. E-mail: i.chopra{at}leeds.ac.uk.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1206-1208, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1206-1208.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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