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Antimicrobial Agents and Chemotherapy, March 2005, p. 884-888, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.884-888.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Evaluation of Ceftobiprole in a Rabbit Model of Aortic Valve Endocarditis Due to Methicillin-Resistant and Vancomycin-Intermediate Staphylococcus aureus

Henry F. Chambers1*

Division of Infectious Diseases, San Francisco General Hospital, and University of California—San Francisco, San Francisco, California1

Received 29 July 2004/ Returned for modification 12 October 2004/ Accepted 11 November 2004

Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the methicillin-resistance determinant of staphylococci, and is active against methicillin- and vancomycin-resistant Staphylococcus aureus. Ceftobiprole was compared to vancomycin in a rabbit model of methicillin-resistant S. aureus aortic valve endocarditis. Ceftobiprole and vancomycin were equally effective against endocarditis caused by methicillin-resistant S. aureus strain 76, whereas ceftobiprole was more effective than vancomycin against the vancomycin-intermediate S. aureus strain HIP5836. The activity of ceftobiprole against drug-resistant strains of S. aureus warrants its further clinical development.

* Mailing address: Division of Infectious Diseases, San Francisco General Hospital, and University of California—San Francisco, Room 3400, Building 30, 1001 Potrero Ave., San Francisco, CA 94110. Phone: (415) 206-5437. Fax: (415) 648-8425. E-mail: chipc{at}itsa.ucsf.edu.

Antimicrobial Agents and Chemotherapy, March 2005, p. 884-888, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.884-888.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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