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Antimicrobial Agents and Chemotherapy, April 2005, p. 1567-1571, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1567-1571.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CTX-M-10 Linked to a Phage-Related Element Is Widely Disseminated among Enterobacteriaceae in a Spanish Hospital

Antonio Oliver,1* Teresa M. Coque,2 Diana Alonso,1 Aránzazu Valverde,2 Fernando Baquero,2 and Rafael Cantón2

Servicio de Microbiología, Hospital Universitario Son Dureta, Palma de Mallorca,1 Servicio de Microbiología, Hospital Universitario Ramón y Cajal, Madrid, Spain2

Received 17 August 2004/ Returned for modification 22 November 2004/ Accepted 17 December 2004

CTX-M-10 has been widely disseminated among multiple clones of several species of Enterobacteriaceae, harboring seemingly different plasmids, for over a decade in Ramón y Cajal University Hospital, Madrid, Spain. Cloning and sequencing of a 12.2-kb DNA fragment from plasmid pRYCE21 from Klebsiella pneumoniae strain KP4aC revealed a novel phage-related element immediately upstream of blaCTX-M-10 conserved among different CTX-M-10-producing strains. This is the first report showing an extended-spectrum-ß-lactamase gene linked to a phage-related element.

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Son Dureta, C. Andrea Doria No. 55, 07014 Palma de Mallorca, Spain. Phone: 34 971 175 185. Fax: 34 971 175 185. E-mail: aoliver{at}hsd.es.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1567-1571, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1567-1571.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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