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Antimicrobial Agents and Chemotherapy, April 2005, p. 1576-1579, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1576-1579.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Excision of Nucleoside Analogs from DNA by p53 Protein, a Potential Cellular Mechanism of Resistance to Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Mary Bakhanashvili,1,2* Elena Novitsky,1 Ethan Rubinstein,1 Itzchak Levy,1 and Galia Rahav1

Infectious Diseases Unit, Chaim Sheba Medical Center, Tel Hashomer,1 Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel2

Received 15 August 2004/ Returned for modification 12 October 2004/ Accepted 28 December 2004

We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.

* Corresponding author. Mailing address: Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel. Phone: 972-3-5303401. Fax: 972-3-5303501. E-mail: bakhanus{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1576-1579, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1576-1579.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wong, T. S., Rajagopalan, S., Townsley, F. M., Freund, S. M., Petrovich, M., Loakes, D., Fersht, A. R. (2009). Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res 37: 568-581 [Abstract] [Full Text]  


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