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Antimicrobial Agents and Chemotherapy, April 2005, p. 1597-1599, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1597-1599.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antifungal Activity of Flocculosin, a Novel Glycolipid Isolated from Pseudozyma flocculosa

Benjamin Mimee,1 Caroline Labbé,1 René Pelletier,2 and Richard R. Bélanger1*

Centre de Recherche en Horticulture, Université Laval,1 Laboratoire de Microbiologie de l'Hôtel-Dieu de Québec du Centre Hospitalier Universitaire de Québec, Québec, Canada2

Received 29 October 2004/ Returned for modification 23 November 2004/ Accepted 26 December 2004

Flocculosin, a glycolipid isolated from the yeast-like fungus Pseudozyma flocculosa, was investigated for in vitro antifungal activity. The compound displayed antifungal properties against several pathogenic yeasts. Synergistic activity was observed between flocculosin and amphotericin B, and no significant cytotoxicity was demonstrated when tested against human cell lines.

* Corresponding author. Mailing address: Département de Phytologie, Centre de Recherche en Horticulture, Université Laval, Québec, Canada G1K 7P4. Phone: (418) 656-2758. Fax: (418) 656-7871. E-mail: richard.belanger{at}plg.ulaval.ca.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1597-1599, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1597-1599.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mimee, B., Labbe, C., Belanger, R. R (2009). Catabolism of flocculosin, an antimicrobial metabolite produced by Pseudozyma flocculosa. Glycobiology 19: 995-1001 [Abstract] [Full Text]  


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