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Antimicrobial Agents and Chemotherapy, April 2005, p. 1622-1625, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1622-1625.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria

Paul N. Newton,1,2 Jean-François Chaulet,3 Alan Brockman,1,4 Wirongrong Chierakul,1 Arjen Dondorp,1,2 Ronatrai Ruangveerayuth,5 Sornchai Looareesuwan,1 Cyril Mounier,3 and Nicholas J. White1,2,4*

Shoklo Malaria Research Unit,4 Mae Sot Hospital, Mae Sot, Tak,5 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,1 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom,2 Laboratoire de biochimie, toxicologie et pharmacologie, Hopital d'Instruction des Armées Desgenettes, Lyon, France3

Received 24 June 2004/ Returned for modification 15 September 2004/ Accepted 3 December 2004

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

* Corresponding author. Mailing address: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: (66) 2 354 9172. Fax: (66) 2 354 9169. E-mail: nickw{at}tropmedres.ac.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1622-1625, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1622-1625.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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