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Antimicrobial Agents and Chemotherapy, April 2005, p. 1649-1651, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1649-1651.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Levofloxacin and Ciprofloxacin Decrease Procainamide and N-Acetylprocainamide Renal Clearances

Larry A. Bauer,1,2* Douglas J. Black,1 Jennifer S. Lill,3 Julie Garrison,3 Vidmantas A. Raisys,2 and Thomas M. Hooton4

Department of Pharmacy, University of Washington, Seattle, Washington,1 Department of Laboratory Medicine, University of Washington, Seattle, Washington,2 Department of Pharmacy Services, University of Washington, Seattle, Washington,3 Department of Medicine, University of Washington, Seattle, Washington4

Received 3 June 2004/ Returned for modification 25 July 2004/ Accepted 17 October 2004

Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

* Corresponding author. Mailing address: Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195. Phone: (206) 685-2713. Fax: (206) 543-3835. E-mail: labauer{at}u.washington.edu.

Antimicrobial Agents and Chemotherapy, April 2005, p. 1649-1651, Vol. 49, No. 4
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.4.1649-1651.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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