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Antimicrobial Agents and Chemotherapy, May 2005, p. 1708-1713, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.1708-1713.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genetic Environment and Expression of the Extended-Spectrum ß-Lactamase blaPER-1 Gene in Gram-Negative Bacteria

Laurent Poirel,1 Ludovic Cabanne,1 Haluk Vahaboglu,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K. Bicêtre, France,1 Infectious Diseases & Clinical Microbiology Department, Kocaeli University Medical School, Kocaeli, Turkey2

Received 22 October 2004/ Returned for modification 6 January 2005/ Accepted 3 February 2005

The genetic location of the gene coding for the expanded-spectrum ß-lactamase PER-1 was analyzed in a series of gram-negative isolates. It was identified as part of a composite transposon bracketed by two novel insertion elements, ISPa12 and ISPa13, belonging to the IS4 family that possess transposases that share 63% amino acid identity and that are chromosomally located in Pseudomonas aeruginosa, Providencia stuartii, and Acinetobacter baumannii. On the contrary, the blaPER-1 gene was identified just downstream of an ISPa12 element but not within a composite transposon when it was located on a plasmid in Salmonella enterica serovar Typhimurium and A. baumannii isolates. In both cases, expression of the blaPER-1 gene was driven by promoter sequences located in ISPa12.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, May 2005, p. 1708-1713, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.1708-1713.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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