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Antimicrobial Agents and Chemotherapy, May 2005, p. 2093-2094, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2093-2094.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Tenofovir in Breast Milk of Lactating Rhesus Macaques

Koen K. A. Van Rompay,1* Marta Hamilton,2,{dagger} Brian Kearney,2 and Norbert Bischofberger2

California National Primate Research Center, University of California, Davis, California 95616,1 Gilead Sciences, Foster City, California 944042

Received 22 September 2004/ Returned for modification 12 November 2004/ Accepted 7 January 2005

To study tenofovir transfer into milk, two lactating macaques were given a subcutaneous dose of tenofovir (30 mg/kg of body weight). Peak concentrations and area under the curve values of tenofovir in milk were ~3 and ~20% of those detected in serum, respectively.

* Corresponding author. Mailing address: California National Primate Research Center, University of California, Davis, CA 95616. Phone: (530) 752-5281. Fax: (530) 754-4411. E-mail: kkvanrompay{at}ucdavis.edu.

{dagger} Present address: OSI Pharmaceuticals, Boulder, CO 80301.

Antimicrobial Agents and Chemotherapy, May 2005, p. 2093-2094, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2093-2094.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Forthal, D. N., Landucci, G., Cole, K. S., Marthas, M., Becerra, J. C., Van Rompay, K. (2006). Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells.. J. Virol. 80: 9217-9225 [Abstract] [Full Text]  


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