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Antimicrobial Agents and Chemotherapy, May 2005, p. 2098-2101, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2098-2101.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Hypermutable and Fluoroquinolone-Resistant Clinical Isolates of Staphylococcus aureus

Hiep N'Guyen Trong, Anne-Laure Prunier, and Roland Leclercq*

Service de Microbiologie and EA 2128 Relations hôte et microorganismes des épithéliums, Hôpital Côte de Nacre, Université de Caen, 14033 Caen cedex, France

Received 11 November 2004/ Returned for modification 16 December 2004/ Accepted 17 January 2005

Over 124 methicillin-susceptible Staphylococcus aureus 0/74 fluoroquinolone-susceptible versus 5/50 fluoroquinolone-resistant isolates were hypermutable. Hypermutable isolates combined mutations in gyrA, parC, and/or parE genes. One strain had a large deletion of the mutator mutS and mutL genes. No relevant mutation in mutS and mutL genes was found in the other isolates.

* Corresponding author. Mailing address: CHU de Caen, Service de Microbiologie, Avenue Côte de Nacre, 14033 Caen Cedex, France. Phone: (33) 02-31-06-45-72. Fax: (33) 02-31-06-45-73. E-mail: leclercq-r{at}chu-caen.fr.

Antimicrobial Agents and Chemotherapy, May 2005, p. 2098-2101, Vol. 49, No. 5
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.5.2098-2101.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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