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Antimicrobial Agents and Chemotherapy, June 2005, p. 2490-2494, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2490-2494.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

DNA in Antibiotic Preparations: Absence of Intact Resistance Genes

Markus Woegerbauer,1,2* Heimo Lagler,1 Wolfgang Graninger,1 and Heinz Burgmann1

Division of Infectious Diseases, Department of Internal Medicine I, University of Vienna, 1090 Vienna, Austria,1 Birkmayer Laboratories, 1090 Vienna, Austria2

Received 4 August 2004/ Returned for modification 10 October 2004/ Accepted 1 February 2005

Fragments of erm(E2), otrA, and aph(6) shorter than 400 bp and producer strain-specific rRNA genes were amplified from various antibiotics. The amount of genetic material and the sizes of amplicons recovered from murine feces after oral administration of a ß-lactamase-encoding plasmid indicated substantial DNA degradation in the mammalian gastrointestinal tract. These observations imply that antibiotics are no major source for horizontal resistance gene transfer in clinical settings.

* Corresponding author. Mailing address: Birkmayer Laboratories, Department of Research and Development, Schwarzspanierstrasse 15, A-1090 Vienna, Austria. Phone: 0043/1/403 17 55-11. Fax: 0043/1/403 17 55-19. E-mail: m.woegerbauer{at}birkmayer.com.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2490-2494, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2490-2494.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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