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Antimicrobial Agents and Chemotherapy, June 2005, p. 2507-2509, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2507-2509.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Activity and Killing Effect of Citropin 1.1 against Gram-Positive Pathogens Causing Skin and Soft Tissue Infections

Andrea Giacometti,1* Oscar Cirioni,1 Wojciech Kamysz,2 Carmela Silvestri,1 Maria Simona Del Prete,1 Alberto Licci,1 Giuseppina D'Amato,1 Jerzy Lukasiak,2 and Giorgio Scalise1

Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy,1 Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland2

Received 5 November 2004/ Returned for modification 12 December 2004/ Accepted 27 January 2005

The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.

* Corresponding author. Mailing address: Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. Phone: 39-071-5963715. Fax: 39-071-5963468. E-mail: anconacmi{at}interfree.it.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2507-2509, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2507-2509.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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