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Antimicrobial Agents and Chemotherapy, June 2005, p. 2515-2518, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2515-2518.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Isolation and Expression of a Novel Molecular Class D ß-Lactamase, OXA-61, from Campylobacter jejuni

David A. Alfredson* and Victoria Korolik

Microbial Glycobiology, Institute for Glycomics, Griffith University, Gold Coast, Southport, Queensland 4215, Australia

Received 22 October 2004/ Returned for modification 6 January 2005/ Accepted 8 February 2005

A novel ß-lactamase gene, blaOXA-61, from Campylobacter jejuni GC015 was cloned and its nucleotide sequence determined. blaOXA-61 encodes a protein of 257 amino acids in which the active-site STFK tetrad and conserved class D ß-lactamase motifs YGN and KTG were identified. A conserved sequence upstream of blaOXA-61 is required for expression in Campylobacter.

* Corresponding author. Mailing address: Microbiology Department, Queensland Health Pathology Services, Gold Coast Hospital, 108 Nerang St., Southport, Queensland, Australia 4215. Phone: 61 7 5519 8497. Fax: 61 7 5519 8496. E-mail: David_Alfredson{at}health.qld.gov.au.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2515-2518, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2515-2518.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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