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Antimicrobial Agents and Chemotherapy, June 2005, p. 2546-2549, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2546-2549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Caspofungin in Combination with Amphotericin B against Candida glabrata

Francesco Barchiesi,1* Elisabetta Spreghini,1 Annette W. Fothergill,3 Daniela Arzeni,1 Gianfranco Greganti,1 Daniele Giannini,2 Michael G. Rinaldi,3,4 and Giorgio Scalise1

Istituto di Malattie Infettive e Medicina Pubblica,1 Centro di Gestione Presidenza Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy,2 Department of Pathology, The University of Texas Health Science Center at San Antonio,3 Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas4

Received 21 December 2004/ Returned for modification 29 January 2005/ Accepted 21 February 2005

The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata. Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model.

* Corresponding author. Mailing address: Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera-Universitaria, Ospedali Riuniti, Umberto I—G.M. Lancisi—G. Salesi, Via Conca 60020, Torrette di Ancona, Ancona, Italy. Phone: 39 071 5963426. Fax: 39 071 5963468. E-mail: l.infettive{at}ao-umbertoprimo.marche.it.

Antimicrobial Agents and Chemotherapy, June 2005, p. 2546-2549, Vol. 49, No. 6
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.6.2546-2549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kiraz, N., Dag, I., Yamac, M., Kiremitci, A., Kasifoglu, N., Akgun, Y. (2009). Antifungal Activity of Caspofungin in Combination with Amphotericin B against Candida glabrata: Comparison of Disk Diffusion, Etest, and Time-Kill Methods. Antimicrob. Agents Chemother. 53: 788-790 [Abstract] [Full Text]  
  • Cota, J. M., Grabinski, J. L., Talbert, R. L., Burgess, D. S., Rogers, P. D., Edlind, T. D., Wiederhold, N. P. (2008). Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin. Antimicrob. Agents Chemother. 52: 1144-1146 [Abstract] [Full Text]  
  • Barchiesi, F., Spreghini, E., Tomassetti, S., Giannini, D., Scalise, G. (2007). Caspofungin in Combination with Amphotericin B against Candida parapsilosis. Antimicrob. Agents Chemother. 51: 941-945 [Abstract] [Full Text]  
  • Marine, M., Serena, C., Pastor, F. J., Guarro, J. (2006). Combined antifungal therapy in a murine infection by Candida glabrata. J Antimicrob Chemother 58: 1295-1298 [Abstract] [Full Text]  


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