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Antimicrobial Agents and Chemotherapy, July 2005, p. 2994-2996, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.2994-2996.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Interactions of Micafungin with Other Antifungal Drugs against Clinical Isolates of Four Species of Cryptococcus

Carolina Serena,1 Belkys Fernández-Torres,1 F. Javier Pastor,1 Luciana Trilles,2 Márcia dos Santos Lazéra,2 Nicole Nolard,3 and Josep Guarro1*

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain,1 Serviço de Micología Médica, Instituto de Pesquisa Clínica Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil,2 Scientific Institute of Public Health, Brussels, Belgium3

Received 3 February 2005/ Returned for modification 3 March 2005/ Accepted 11 March 2005

The combination of micafungin (MFG) with amphotericin B (AMB), fluconazole, itraconazole, voriconazole, or ravuconazole was evaluated against 37 strains of four species of Cryptococcus by the checkerboard method. Antagonism was never seen. Synergy was observed for some isolates for each combination and was most frequent with MFG-AMB.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: josep.guarro{at}urv.net.

Antimicrobial Agents and Chemotherapy, July 2005, p. 2994-2996, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.2994-2996.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Serena, C., Marine, M., Quindos, G., Carrillo, A. J., Cano, J. F., Pastor, F. J., Guarro, J. (2008). In Vitro Interactions of Micafungin with Amphotericin B against Clinical Isolates of Candida spp.. Antimicrob. Agents Chemother. 52: 1529-1532 [Abstract] [Full Text]  
  • Rodriguez, M. M., Ruiz, M., Pastor, F. J., Quindos, G., Carrillo, A., Guarro, J. (2007). In vitro interaction of micafungin and fluconazole against Candida. J Antimicrob Chemother 60: 188-190 [Full Text]  
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