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Antimicrobial Agents and Chemotherapy, July 2005, p. 3001-3003, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3001-3003.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Broader Distribution of Plasmid-Mediated Quinolone Resistance in the United States

A. Robicsek,1 D. F. Sahm,2 J. Strahilevitz,1 G. A. Jacoby,3 and D. C. Hooper1*

Massachusetts General Hospital, Boston, Massachusetts,1 Focus Technologies, Herndon, Virginia,2 Lahey Clinic, Burlington, Massachusetts3

Received 10 March 2005/ Returned for modification 3 April 2005/ Accepted 21 April 2005

The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.

* Corresponding author. Mailing address: Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114-2696. Phone: (617) 726-3812. Fax: (617) 726-7416. E-mail: dhooper{at}partners.org.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3001-3003, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3001-3003.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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