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Antimicrobial Agents and Chemotherapy, July 2005, p. 3011-3013, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3011-3013.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Time-Kill Study of the Activity of Telithromycin against Macrolide-Resistant Streptococcus pneumoniae Isolates with 23S rRNA Mutations and Changes in Ribosomal Proteins L4 and L22

Ralf René Reinert* and Adnan Al-Lahham

Institute of Medical Microbiology, National Reference Centre for Streptococci, University of Aachen (RWTH-Aachen), Aachen, Germany

Received 11 February 2005/ Returned for modification 10 March 2005/ Accepted 15 March 2005

By use of a time-kill methodology, the antipneumococcal activity of telithromycin was determined against macrolide-resistant S. pneumoniae isolates having mutations in the 23S rRNA gene and changes in the ribosomal proteins L4 and L22. Telithromycin had MICs ranging between 0.03 and 0.25 µg/ml and was bactericidal against four of seven strains after 24 h at two times the MIC.

* Corresponding author. Mailing address: Institute of Medical Microbiology, National Reference Centre for Streptococci, University of Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany. Phone: 49 241 80 89 787. Fax: 49 241 8082 483. E-mail: reinert{at}rwth-aachen.de.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3011-3013, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3011-3013.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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