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Antimicrobial Agents and Chemotherapy, July 2005, p. 3018-3020, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3018-3020.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Emergence of KPC-Possessing Klebsiella pneumoniae in Brooklyn, New York: Epidemiology and Recommendations for Detection

Simona Bratu,1 Mohamad Mooty,1 Satyen Nichani,1 David Landman,1 Carl Gullans,2 Barbara Pettinato,3 Usha Karumudi,1 Pooja Tolaney,1 and John Quale1*

Department of Medicine, SUNY-Downstate Medical Center,1 Department of Microbiology, Kings County Hospital,2 Department of Pathology Services, Coney Island Hospital, Brooklyn, New York3

Received 14 February 2005/ Returned for modification 24 March 2005/ Accepted 3 April 2005

Among 257 isolates of Klebsiella pneumoniae collected in Brooklyn, NY, 24% were found to possess blaKPC. Clinical microbiology laboratories that used automated broth microdilution systems reported 15% of the KPC-possessing isolates as susceptible to imipenem. The imipenem MIC was found to be markedly affected by the inoculum. For accurate detection of KPC-possessing K. pneumoniae, particular attention should be paid to proper inoculum preparation for broth-based susceptibility methods. In addition, using ertapenem or meropenem for class reporting of carbapenem susceptibility will improve detection.

* Corresponding author. Mailing address: SUNY Downstate, Box 77 Division of Infectious Diseases, 450 Clarkson Avenue, Brooklyn, NY 11203. Phone: (718) 270-2148. Fax: (718) 270-2465. E-mail: jquale{at}downstate.edu.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3018-3020, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3018-3020.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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