This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Le Ray, A.-M.
Right arrow Articles by Caillon, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Le Ray, A.-M.
Right arrow Articles by Caillon, J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, July 2005, p. 3025-3027, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3025-3027.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro and In Vivo Bactericidal Activities of Vancomycin Dispersed in Porous Biodegradable Poly({varepsilon}-Caprolactone) Microparticles

Anne-Marie Le Ray,1,2 Hélène Gautier,1,2 Marie-Katel Laty,2 Guy Daculsi,1 Christian Merle,1,2 Cédric Jacqueline,3 Antoine Hamel,3 and Jocelyne Caillon3*

Centre de Recherche sur les Matériaux d'Intérêt Biologique, Equipe INSERM 99-03, UFR Odontologie,1 Laboratoire de Pharmacie Galénique, UFR de Pharmacie,2 UPRES EA 3826, UFR de Médecine, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France3

Received 18 October 2004/ Returned for modification 15 November 2004/ Accepted 23 March 2005

Treatment of methicillin-resistant Staphylococcus aureus osteomyelitis requires a prolonged antibiotic therapy with vancomycin. Because of its weak diffusion, the in situ implantation of vancomycin could be interesting. The activity of vancomycin encapsulated in microparticles was evaluated in vitro and in vivo on rabbit osteomyelitis and showed a good activity compared to intravenous administration.

* Corresponding author. Mailing address: Laboratoire de Microbiologie, EA 3826, UFR de Médecine, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France. Phone and fax: (33) 240-412-854. E-mail: jocelyne.caillon{at}univ-nantes.fr.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3025-3027, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3025-3027.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cai, X.-Z., Yan, S.-G., Wu, H.-B., He, R.-X., Dai, X.-S., Chen, H.-X., Yan, R.-J., Zhao, X.-H. (2007). Effect of Delayed Pulsed-Wave Ultrasound on Local Pharmacokinetics and Pharmacodynamics of Vancomycin-Loaded Acrylic Bone Cement In Vivo. Antimicrob. Agents Chemother. 51: 3199-3204 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»