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Antimicrobial Agents and Chemotherapy, July 2005, p. 3034-3039, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3034-3039.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of an Oral Streptogramin Antimicrobial, XRP2868, against Gram-Positive Bacteria

G. M. Eliopoulos,1,3* M. J. Ferraro,2,3 C. B. Wennersten,1 and R. C. Moellering Jr.1,3

Department of Medicine, Beth Israel Deaconess Medical Center,1 Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114and,2 Harvard Medical School, Boston, Massachusetts 021153

Received 4 February 2005/ Returned for modification 1 March 2005/ Accepted 20 April 2005

The comparative in vitro potency of XRP2868, a new oral semisynthetic streptogramin antibiotic, was evaluated against gram-positive bacteria. XRP2868 inhibited all staphylococci at ≤1 µg/ml and all nonpneumococcal streptococci at ≤0.25 µg/ml and was fourfold more potent than quinupristin-dalfopristin against Staphylococcus aureus and Enterococcus faecium.

* Corresponding author. Mailing address: Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. Phone: (617) 632-7434. Fax: (617) 632-7439. E-mail: geliopou{at}bidmc.harvard.edu.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3034-3039, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3034-3039.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Dupuis, M., Leclercq, R. (2006). Activity of a New Oral Streptogramin, XRP2868, against Gram-Positive Cocci Harboring Various Mechanisms of Resistance to Streptogramins. Antimicrob. Agents Chemother. 50: 237-242 [Abstract] [Full Text]  


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