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Antimicrobial Agents and Chemotherapy, July 2005, p. 3087-3090, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3087-3090.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Sublethal Concentrations of Ciprofloxacin Induce Bacteriocin Synthesis in Escherichia coli

Borut Jerman, Matej Butala, and Darja Zgur-Bertok*

Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia

Received 18 December 2004/ Returned for modification 10 January 2005/ Accepted 4 April 2005

Antibiotics that interfere with DNA replication, as well as cell wall synthesis, induce the SOS response. In this report, we show that ciprofloxacin induces synthesis of colicins, narrow-spectrum antibiotics frequently produced by Escherichia coli strains, in an SOS-dependent manner.

* Corresponding author. Mailing address: Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia. Phone: 368 1 423 3388. Fax: 386 1 257 3390. E-mail: darja.zgur.bertok{at}bf.uni-lj.si.

Antimicrobial Agents and Chemotherapy, July 2005, p. 3087-3090, Vol. 49, No. 7
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.7.3087-3090.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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