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Antimicrobial Agents and Chemotherapy, August 2005, p. 3486-3488, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3486-3488.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Caspofungin Susceptibility Testing of Candida inconspicua: Correlation of Different Methods with the Minimal Fungicidal Concentration

L. Majoros,1* G. Kardos,1 B. Szabó,1,2 and M. Sipiczki3

Department of Medical Microbiology, University of Debrecen, Debrecen, Hungary,1 Faculty of Health Sciences, University of Debrecen, Debrecen, Hungary,2 Department of Genetics, University of Debrecen, Debrecen, Hungary3

Received 27 January 2005/ Returned for modification 27 March 2005/ Accepted 15 May 2005

Minimal inhibitory and minimal fungicidal concentrations of caspofungin were determined for 48 Candida inconspicua isolates. By using CLSI (formerly NCCLS) methodology with the partial inhibition endpoint criterion, caspofungin exhibited a good fungicidal effect against C. inconspicua (the MIC90 was 0.25 µg/ml and the minimum fungicidal concentration [MFC] was 0.5 µg/ml after 24 h). Total inhibition yielded falsely elevated MICs, exceeding even the respective MFCs.

* Corresponding author. Mailing address: Department of Medical Microbiology, University of Debrecen, 4032 Debrecen, Nagyerdei krt. 98, Hungary. Phone: 52-411-717/4501. Fax: 52-414-948. E-mail: major{at}jaguar.dote.hu.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3486-3488, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3486-3488.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Soczo, G., Kardos, G., Varga, I., Kelentey, B., Gesztelyi, R., Majoros, L. (2007). In Vitro Study of Candida tropicalis Isolates Exhibiting Paradoxical Growth in the Presence of High Concentrations of Caspofungin. Antimicrob. Agents Chemother. 51: 4474-4476 [Abstract] [Full Text]  
  • Pfaller, M. A., Diekema, D. J. (2007). Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem. Clin. Microbiol. Rev. 20: 133-163 [Abstract] [Full Text]  


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