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Antimicrobial Agents and Chemotherapy, August 2005, p. 3513-3516, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3513-3516.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effects of Daptomycin, Linezolid, and Vancomycin on Establishment of Intestinal Colonization with Vancomycin-Resistant Enterococci and Extended-Spectrum-ß-Lactamase-Producing Klebsiella pneumoniae in Mice

Nicole J. Pultz,1 Usha Stiefel,2 and Curtis J. Donskey1,3*

Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio,1 Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio,2 Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio3

Received 23 November 2004/ Returned for modification 24 January 2005/ Accepted 7 May 2005

In mice, vancomycin and linezolid treatment disrupted the anaerobic intestinal microflora, based on denaturing gradient gel electrophoresis analysis, and promoted colonization by Klebsiella pneumoniae and vancomycin-resistant enterococci. However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen.

* Corresponding author. Mailing address: Infectious Diseases Section (111 W), Louis Stokes Cleveland VA Medical Center, 10701 East Blvd., Cleveland, Ohio 44106. Phone: (216) 791-3800, ext. 5103. E-mail: curtisd123{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3513-3516, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3513-3516.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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