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Antimicrobial Agents and Chemotherapy, August 2005, p. 3517-3519, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3517-3519.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Preincubation of Pneumococci with ß-Lactams Alone or Combined with Levofloxacin Prevents Quinolone-Induced Resistance without Increasing Intracellular Levels of Levofloxacin

Philippe Cottagnoud,1* Maggie Johnson,2 Marianne Cottagnoud,3 and Laura Piddock2

Department of Internal Medicine, Inselspital Bern, Freiburgstrasse, 3010 Bern, Switzerland,1 Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, United Kingdom,2 Clinic of Internal Medicine, Spital Bern-Ziegler, Morillonstrasse 75-91, 3007 Bern, Switzerland3

Received 27 October 2004/ Returned for modification 16 February 2005/ Accepted 20 April 2005

Preincubation of pneumococci with sub-MIC concentrations of ceftriaxone (1/16x MIC), cefotaxime (1/8x MIC), and meropenem (1/4x MIC) alone or combined with levofloxacin (1/8x MIC) over 6 h prevents the emergence of levofloxacin-resistant mutants after 96 h of incubation but does not affect the intracellular accumulation of levofloxacin in two penicillin-resistant pneumococcal strains, suggesting a link between the mechanism of action of ß-lactams and the emergence of quinolone-induced resistance in pneumococci.

* Corresponding author. Mailing address: Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland. Phone: 41-31-632-34-72. Fax: 41-31-632-38-47. E-mail: pcottagn{at}insel.ch.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3517-3519, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3517-3519.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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