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Antimicrobial Agents and Chemotherapy, August 2005, p. 3544-3545, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3544-3545.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Interaction of Posaconazole and Caspofungin against Clinical Isolates of Candida glabrata

E. R. Oliveira,1* A. W. Fothergill,2 W. R. Kirkpatrick,3 B. J. Coco,3 T. F. Patterson,3 and S. W. Redding1

Department of General Dentistry,1 Department of Pathology,2 Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center, San Antonio, Texas 78229-39003

Received 27 January 2005/ Returned for modification 21 February 2005/ Accepted 11 May 2005

Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.

* Corresponding author. Mailing address: Department of General Dentistry, University of Texas Health Science Center at San Antonio, Mail Code 7914, 7703 Floyd Curl Drive, San Antonio, TX 78229. Phone: (210) 567-3441. Fax: (210) 567-3443. E-mail: oliveirae{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3544-3545, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3544-3545.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Morris, M. I. (2009). Posaconazole: A new oral antifungal agent with an expanded spectrum of activity. Am J Health Syst Pharm 66: 225-236 [Abstract] [Full Text]  
  • Guembe, M., Guinea, J., Pelaez, T., Torres-Narbona, M., Bouza, E. (2007). Synergistic Effect of Posaconazole and Caspofungin against Clinical Zygomycetes. Antimicrob. Agents Chemother. 51: 3457-3458 [Full Text]  


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