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Antimicrobial Agents and Chemotherapy, August 2005, p. 3569-3571, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3569-3571.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Isocratic High-Performance Liquid Chromatographic Method with Ultraviolet Detection for Simultaneous Determination of Levels of Voriconazole and Itraconazole and Its Hydroxy Metabolite in Human Serum

GholamAli Khoschsorur,* Franz Fruehwirth, and Sieglinde Zelzer

Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

Received 2 March 2005/ Returned for modification 21 March 2005/ Accepted 20 May 2005

A simple, specific method is presented for simultaneous determination of voriconazole and itraconazole and its metabolite, hydroxyitraconazole, in human serum using one-step liquid-liquid extraction and high-performance liquid chromatography. Linearity tests ranged from 0.1 to 8.0 µg/ml; the minimum detectable concentration was 0.03 µg/ml.

* Corresponding author. Mailing address: Institute of Medical and Chemical Laboratory Diagnostics (LB.I), Auenbruggerplatz 29, A-8036 Graz, Austria. Phone: 316-385-2296. Fax: 316-385-3419. E-mail: g.Khoschsorur{at}klinikum-graz.at.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3569-3571, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3569-3571.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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