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Antimicrobial Agents and Chemotherapy, August 2005, p. 3572-3574, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3572-3574.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vitro Synergy Testing of Anidulafungin with Itraconazole, Voriconazole, and Amphotericin B against Aspergillus spp. and Fusarium spp.

Annie Philip, Zekaver Odabasi, Jose Rodriguez, Victor L. Paetznick, Enuo Chen, John H. Rex,{dagger} and Luis Ostrosky-Zeichner*

Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas-Houston Medical School, Houston, Texas 77030

Received 25 January 2005/ Returned for modification 9 March 2005/ Accepted 6 May 2005

The in vitro interactions of anidulafungin with itraconazole, voriconazole, and amphotericin B were evaluated by using the checkerboard method. For Aspergillus spp., anidulafungin with amphotericin B showed indifference for 16/26 isolates, while anidulafungin with either azole showed a synergy trend for 18/26 isolates. All drug combinations showed indifference for 7/7 Fusarium sp. isolates.

* Corresponding author. Mailing address: Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas—Houston Medical School, 6431 Fannin, MSB 2.112, Houston, TX 77030. Phone: (713) 500-6733. Fax: (713) 500-5495. E-mail: Luis.Ostrosky-Zeichner{at}uth.tmc.edu.

{dagger} Present address: AstraZeneca Pharmaceuticals, Alderley House, Alderley Park, Macclesfield, United Kingdom.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3572-3574, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3572-3574.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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