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Antimicrobial Agents and Chemotherapy, August 2005, p. 3586-3589, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3586-3589.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Prevalence of Resistance Mechanisms against Macrolides and Lincosamides in Methicillin-Resistant Coagulase-Negative Staphylococci in the Czech Republic and Occurrence of an Undefined Mechanism of Resistance to Lincosamides

Gabriela Novotna,1 Václava Adamkova,2 Jiri Janata,1* Oto Melter,3 and Jaroslav Spizek1

Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic,1 Third Faculty of Medicine, Charles University, Prague, Czech Republic,2 National Institute of Public Health, Prague, Czech Republic3

Received 1 October 2004/ Returned for modification 30 November 2004/ Accepted 14 May 2005

High occurrence of the non-macrolide-lincosamide-streptogramin B resistance genes msrA (53%) and linA/linA' (30%) was found among 98 methicillin-resistant coagulase-negative staphylococci additionally resistant to macrolides and/or lincosamides. The gene msrA predominated in Staphylococcus haemolyticus (43 of 62 isolates). In Staphylococcus epidermidis, it was present in 7 of 27 isolates. A novel mechanism of resistance to lincosamides appears to be present in 10 genetically related isolates of S. haemolyticus in the absence of ermA, ermC, msrA, and linA/linA'.

* Corresponding author. Mailing address: Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 14220, Czechoslovakia. Phone: 0420241062370. E-mail: janata{at}biomed.cas.cz.

Antimicrobial Agents and Chemotherapy, August 2005, p. 3586-3589, Vol. 49, No. 8
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.8.3586-3589.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Soge, O. O., Meschke, J. S., No, D. B., Roberts, M. C. (2009). Characterization of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus spp. isolated from US West Coast public marine beaches. J Antimicrob Chemother 64: 1148-1155 [Abstract] [Full Text]  
  • Novotna, G., Janata, J. (2006). A New Evolutionary Variant of the Streptogramin A Resistance Protein, Vga(A)LC, from Staphylococcus haemolyticus with Shifted Substrate Specificity towards Lincosamides. Antimicrob. Agents Chemother. 50: 4070-4076 [Abstract] [Full Text]  


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