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Antimicrobial Agents and Chemotherapy, September 2005, p. 3910-3918, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3910-3918.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effect of Medium Age and Supplementation with the Biocatalytic Oxygen-Reducing Reagent Oxyrase on In Vitro Activities of Tigecycline against Recent Clinical Isolates

Peter J. Petersen* and Patricia A. Bradford

Infectious Disease Discovery Research, Microbiology, Wyeth Research, Pearl River, New York 10965

Received 18 March 2005/ Returned for modification 3 May 2005/ Accepted 21 June 2005

In determining the quality control limits for the Clinical Laboratory Standards Institute-recommended quality control organisms with tigecycline, a number of inconsistencies in the results were encountered that appeared to be related to the age of the Mueller-Hinton broth II. This study was performed to examine the effect of medium age and supplementation with Oxyrase on the activity of tigecycline using a large number of clinical isolates.

* Corresponding author. Mailing address: Infectious Disease Research, Wyeth Research, Bldg. 200, Rm. 3301, 401 N. Middletown Rd., Pearl River, NY 10965. Phone: (845) 602-3070. Fax: (845) 602-5671. E-mail: petersp{at}wyeth.com.

Antimicrobial Agents and Chemotherapy, September 2005, p. 3910-3918, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3910-3918.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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