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Antimicrobial Agents and Chemotherapy, September 2005, p. 3963-3965, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3963-3965.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Postantibiotic Effect of DX-619 against 16 Gram-Positive Organisms

G. A. Pankuch and P. C. Appelbaum*

Departments of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Received 2 March 2005/ Returned for modification 29 April 2005/ Accepted 20 June 2005

The in vitro postantibiotic effects (PAEs), the postantibiotic sub-MIC effects (PA-SMEs), and the sub-MIC effects (SMEs) of DX-619 were determined for 16 gram-positive organisms. DX-619 pneumococcal, staphylococcal, and enterococcal PAE ranges were 1.7 to 5.0 h, 0.7 to 1.8 h, and 1.2 to 6.5 h, respectively. The PA-SME ranges (0.4x MIC) for pneumococci, staphylococci, and enterococci were 5.2 to >8.6 h, 2.1 to 8.3 h, and 4.9 to >10.0 h, respectively.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, September 2005, p. 3963-3965, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3963-3965.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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