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Antimicrobial Agents and Chemotherapy, September 2005, p. 3966-3969, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3966-3969.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Nevirapine Plasma Exposure Affects both Durability of Viral Suppression and Selection of Nevirapine Primary Resistance Mutations in a Clinical Setting

D. González de Requena,1 S. Bonora,1 S. Garazzino,1 M. Sciandra,1 A. D'Avolio,1 R. Raiteri,1 R. Marrone,1 M. Boffito,2 F. G. De Rosa,1 A. Sinicco,1 and G. Di Perri1*

Department of Infectious Diseases, University of Turin, Turin, Italy,1 Chelsea and Westminster Hospital, London, England2

Received 8 November 2004/ Returned for modification 28 January 2005/ Accepted 27 May 2005

The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration (Ctrough) of >4,300 ng/ml was found to predict longer VS. Patients with nevirapine Ctroughs ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than those with nevirapine Ctroughs below and above this concentration interval.

* Corresponding author. Mailing address: Clinica di Malattie Infettive dell'Universitá di Torino, Ospedale Amedeo di Savoia, Corso Svizzera, 164, 10149 Torino, Italy. Phone: 39 011 4393996. Fax: 39 011 744971. E-mail: danifarre{at}hotmail.com.

Antimicrobial Agents and Chemotherapy, September 2005, p. 3966-3969, Vol. 49, No. 9
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.9.3966-3969.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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