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Antimicrobial Agents and Chemotherapy, January 2006, p. 148-155, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.148-155.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Moxifloxacin against 923 Anaerobes Isolated from Human Intra-Abdominal Infections

Ellie J. C. Goldstein,1,2* Diane M. Citron,1 Yumi A. Warren,1 Kerin L. Tyrrell,1 C. Vreni Merriam,1 and Helen Fernandez1

R. M. Alden Research Laboratory, Santa Monica, California 90404,1 the UCLA School of Medicine, Los Angeles, California 900732

Received 3 June 2005/ Returned for modification 30 July 2005/ Accepted 28 September 2005

The in vitro activity of moxifloxacin against 923 recent anaerobic isolates obtained from pretreatment cultures in patients with complicated intra-abdominal infections was studied using the CLSI M11-A-6 agar dilution method. Moxifloxacin was active against 87% (96 of 110) Bacteroides fragilis strains at ≤1 µg/ml and 87% (79 of 90) B. thetaiotaomicron strains at ≤2 µg/ml. Species variation was seen, with B. uniformis, B. vulgatus, Clostridium clostridioforme, and C. symbiosum being least susceptible and accounting for most of the resistant isolates; excluding the aforementioned four resistant species, 86% (303 of 363) of Bacteroides species isolates and 94% (417 of 450) of all other genera and species were susceptible to ≤2 µg/ml of moxifloxacin. Overall, moxifloxacin was active against 763 of 923 (83%) of strains at ≤2 µg/ml, supporting its use as a monotherapy for some community-acquired intra-abdominal infections.

* Corresponding author. Mailing address: R. M. Alden Research Laboratory, 2021 Santa Monica Blvd., Suite #740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: ejcgmd{at}aol.com.

Antimicrobial Agents and Chemotherapy, January 2006, p. 148-155, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.148-155.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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