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Antimicrobial Agents and Chemotherapy, January 2006, p. 294-297, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.294-297.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pentamidine Is Active in a Neutropenic Murine Model of Acute Invasive Pulmonary Fusariosis

Michail S. Lionakis,1,2,{dagger} Georgios Chamilos,1,{dagger} Russell E. Lewis,1,3 Nathan P. Wiederhold,3 Issam I. Raad,1 George Samonis,2 and Dimitrios P. Kontoyiannis1,3*

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas,1 Medical School of the University of Crete, Heraklion, Greece,2 College of Pharmacy, University of Houston, Houston, Texas3

Received 11 August 2005/ Returned for modification 12 September 2005/ Accepted 12 October 2005

We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.

* Corresponding author. Mailing address: Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030. Phone: (713) 792-6237. Fax: (713) 745-6839. E-mail: dkontoyi{at}mdanderson.org.

{dagger} These authors contributed equally to this work.

Antimicrobial Agents and Chemotherapy, January 2006, p. 294-297, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.294-297.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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