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Antimicrobial Agents and Chemotherapy, January 2006, p. 332-335, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.332-335.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vivo and In Vitro Studies of Antibiotic Release from and Bacterial Growth Inhibition by Antibiotic-Impregnated Polymethylmethacrylate Hip Spacers

Jens Kelm,1* Thilo Regitz,2 Eduard Schmitt,1 Werner Jung,3 and Konstantinos Anagnostakos1

Klinik für Orthopädie und Orthopädische Chirurgie, Homburg/Saar, Germany,1 Firma Regitz, Kirkel, Germany,2 Abteilung für Bakteriologie und Hygiene, Institut für Medizinische Mikrobiologie und Hygiene der Universitätskliniken des Saarlandes, Homburg/Saar, Germany3

Received 8 April 2005/ Returned for modification 31 May 2005/ Accepted 10 October 2005

The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wound healing cannot be insufficient antibiotic release.

* Corresponding author. Mailing address: MD, Diplom-Sportlehrer, Orthopädische Universitätsklinik, 66421 Homburg/Saar, Germany. Phone: 49-6841/1624520. Fax: 49-6841/1624516. E-mail: jk66421{at}hotmail.com.

Antimicrobial Agents and Chemotherapy, January 2006, p. 332-335, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.332-335.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cai, X.-Z., Yan, S.-G., Wu, H.-B., He, R.-X., Dai, X.-S., Chen, H.-X., Yan, R.-J., Zhao, X.-H. (2007). Effect of Delayed Pulsed-Wave Ultrasound on Local Pharmacokinetics and Pharmacodynamics of Vancomycin-Loaded Acrylic Bone Cement In Vivo. Antimicrob. Agents Chemother. 51: 3199-3204 [Abstract] [Full Text]  


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