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Antimicrobial Agents and Chemotherapy, January 2006, p. 351-354, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.351-354.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The K101P and K103R/V179D Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nonnucleoside Reverse Transcriptase Inhibitors

Neil T. Parkin,* Soumi Gupta, Colombe Chappey, and Christos J. Petropoulos

Monogram Biosciences, 345 Oyster Point Boulevard, South San Francisco, California 94080

Received 23 August 2005/ Returned for modification 26 September 2005/ Accepted 4 October 2005

Genotypic patterns associated with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in the absence of well-characterized resistance mutations were identified using a database (n > 47,000) of phenotype-genotype data. Among samples with no known NNRTI mutations, the most resistant samples contained K101P (n = 35) or a combination of K103R and V179D (n = 41). Site-directed mutagenesis confirmed the importance of these mutations.

* Corresponding author. Mailing address: Monogram Biosciences, Inc., 345 Oyster Point Blvd., South San Francisco, CA 94080. Phone: (650) 866-7438. Fax: (650) 635-1111. E-mail: nparkin{at}monogrambio.com.

Antimicrobial Agents and Chemotherapy, January 2006, p. 351-354, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.351-354.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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