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Antimicrobial Agents and Chemotherapy, January 2006, p. 368-370, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.368-370.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Fosfomycin against Extended-Spectrum-ß-Lactamase- Producing Escherichia coli and Klebsiella pneumoniae: Comparison of Susceptibility Testing Procedures

M. de Cueto,* L. López, J. R. Hernández, C. Morillo, and A. Pascual

Departamento de Microbiología, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Seville, Spain

Received 24 June 2005/ Returned for modification 21 August 2005/ Accepted 28 October 2005

The agar dilution, broth microdilution, and disk diffusion methods were compared to determine the in vitro susceptibility of 428 extended-spectrum-ß-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae to fosfomycin. Fosfomycin showed very high activity against all ESBL-producing strains. Excellent agreement between the three susceptibility methods was found for E. coli, whereas marked discrepancies were observed for K. pneumoniae.

* Corresponding author. Mailing address: Departamento de Microbiología Hospital Universitario Virgen Macarena, Avda. Dr. Fedriani núm 3, 41009, Sevilla, Spain. Phone: 34-955-008287. Fax: 34-954-377413. E-mail: m{at}marinadecueto.e.telefonica.net.

Antimicrobial Agents and Chemotherapy, January 2006, p. 368-370, Vol. 50, No. 1
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.1.368-370.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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