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Antimicrobial Agents and Chemotherapy, October 2006, p. 3464-3466, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00558-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Efficacy of Ambruticin Analogs in a Murine Model of Invasive Pulmonary Aspergillosis

Lisa Y. Chiang,1 Daniele E. Ejzykowicz,1 Zong-Qiang Tian,2 Leonard Katz,2 and Scott G. Filler1,3*

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance,1 Kosan Biosciences, Inc. Hayward,2 David Geffen School of Medicine at UCLA, Los Angeles, California3

Received 5 May 2006/ Returned for modification 16 June 2006/ Accepted 11 July 2006

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

* Corresponding author. Mailing address: Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502. Phone: (310) 222-3813. Fax: (310) 782-2016. E-mail: sfiller{at}ucla.edu.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3464-3466, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00558-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Vetcher, L., Menzella, H. G., Kudo, T., Motoyama, T., Katz, L. (2007). The Antifungal Polyketide Ambruticin Targets the HOG Pathway. Antimicrob. Agents Chemother. 51: 3734-3736 [Abstract] [Full Text]  


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