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Antimicrobial Agents and Chemotherapy, October 2006, p. 3470-3472, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00577-06

Maribavir Antagonizes the Antiviral Action of Ganciclovir on Human Cytomegalovirus

Sunwen Chou* and Gail I. Marousek

Medical and Research Services, VA Medical Center and Oregon Health & Science University, Portland, Oregon

Received 10 May 2006/ Returned for modification 19 June 2006/ Accepted 25 July 2006

The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir antagonized the anti-CMV effect of ganciclovir, increasing the ganciclovir 50% inhibitory concentration against a sensitive strain by up to 13-fold. Antiviral activities of foscarnet and cidofovir were unaffected by maribavir.

* Corresponding author. Mailing address: VA Medical Center P3ID, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239. Phone: (503) 273-5115. Fax: (503) 273-5116. E-mail: chous{at}ohsu.edu.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3470-3472, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00577-06




This article has been cited by other articles:

  • Boeckh, M., Ljungman, P. (2009). How we treat cytomegalovirus in hematopoietic cell transplant recipients. Blood 113: 5711-5719 [Abstract] [Full Text]  
  • Trofe, J., Pote, L., Wade, E., Blumberg, E., Bloom, R. D (2008). Maribavir: A Novel Antiviral Agent with Activity Against Cytomegalovirus. The Annals of Pharmacotherapy 42: 1447-1457 [Abstract] [Full Text]  
  • Chou, S., Marousek, G. I. (2008). Accelerated Evolution of Maribavir Resistance in a Cytomegalovirus Exonuclease Domain II Mutant. J. Virol. 82: 246-253 [Abstract] [Full Text]  


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