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Antimicrobial Agents and Chemotherapy, October 2006, p. 3496-3498, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00741-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Susceptibility of Breakthrough Candida Bloodstream Isolates Correlates with Daily and Cumulative Doses of Fluconazole

Cornelius J. Clancy,1,2* Benjamin Staley,3 and M. Hong Nguyen1,2

Department of Medicine, University of Florida College of Medicine,1 North Florida/South Georgia Veterans Health System,2 Pharmacy Department, Shands Teaching Hospital at the University of Florida, Gainesville, Florida3

Received 16 June 2006/ Returned for modification 8 July 2006/ Accepted 15 July 2006

We determined MICs for 28 Candida isolates recovered from patients who developed breakthrough candidemia while receiving fluconazole. MICs correlated with daily and cumulative doses of fluconazole. Patients receiving ≥2,000 mg cumulatively or >200 mg daily were more likely to be infected with isolates that were not fluconazole susceptible.

* Corresponding author. Mailing address: University of Florida College of Medicine, Department of Medicine, Box 100277 JHMHC, 1600 SW Archer Rd., Gainesville, FL 32610. Phone: (352) 392-4058. Fax: (352) 271-4566. E-mail: clancyn{at}medicine.ufl.edu.

Antimicrobial Agents and Chemotherapy, October 2006, p. 3496-3498, Vol. 50, No. 10
0066-4804/06/$08.00+0     doi:10.1128/AAC.00741-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wade, K. C., Wu, D., Kaufman, D. A., Ward, R. M., Benjamin, D. K. Jr., Sullivan, J. E., Ramey, N., Jayaraman, B., Hoppu, K., Adamson, P. C., Gastonguay, M. R., Barrett, J. S., on behalf of the NICHD Pediatric Pharmacology Rese, (2008). Population Pharmacokinetics of Fluconazole in Young Infants. Antimicrob. Agents Chemother. 52: 4043-4049 [Abstract] [Full Text]  
  • Baddley, J. W., Patel, M., Bhavnani, S. M., Moser, S. A., Andes, D. R. (2008). Association of Fluconazole Pharmacodynamics with Mortality in Patients with Candidemia. Antimicrob. Agents Chemother. 52: 3022-3028 [Abstract] [Full Text]  


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