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Antimicrobial Agents and Chemotherapy, November 2006, p. 3889-3892, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00889-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Thymidine Kinase Mutations Conferring Acyclovir Resistance in Herpes Simplex Type 1 Recombinant Viruses{triangledown}

Yan Sergerie and Guy Boivin*

Research Center in Infectious Diseases of the CHUQ-CHUL and Laval University, Québec City, QC, Canada

Received 18 July 2006/ Returned for modification 8 August 2006/ Accepted 5 September 2006

Contributions of thymidine kinase (TK) mutations to acyclovir (ACV) resistance were evaluated in herpes simplex virus type 1 recombinant viruses generated using a set of overlapping cosmids and plasmids. Alterations in both conserved and nonconserved regions of the TK gene were shown to confer high levels of resistance to ACV.

* Corresponding author. Mailing address: CHUQ-CHUL, room RC-709, 2705, blvd Laurier, Sainte-Foy, Québec, Canada G1V 4G2. Phone: (418) 654-2705. Fax: (418) 654-2715. E-mail: guy.boivin{at}crchul.ulaval.ca.

{triangledown} Published ahead of print on 18 September 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3889-3892, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00889-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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