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Antimicrobial Agents and Chemotherapy, November 2006, p. 3893-3896, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00616-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Synergy between Efflux Pump CmeABC and Modifications in Ribosomal Proteins L4 and L22 in Conferring Macrolide Resistance in Campylobacter jejuni and Campylobacter coli{triangledown}

Cédric Cagliero, Christian Mouline, Axel Cloeckaert, and Sophie Payot*

Institut National de la Recherche Agronomique, UR1282 Infectiologie Animale et Santé Publique (IASP-213), 37380 Nouzilly, France

Received 19 May 2006/ Returned for modification 21 July 2006/ Accepted 16 August 2006

Macrolide-resistant mutants of Campylobacter jejuni and Campylobacter coli were selected in vitro using erythromycin and tylosin. These mutants exhibited modifications in the ribosomal proteins L4 (G74D) and L22 (insertions at position 86 or 98). A synergy between the CmeABC efflux pump and these modifications in conferring macrolide resistance was observed.

* Corresponding author. Mailing address: Institut National de la Recherche Agronomique, UR1282 Infectiologie Animale et Santé Publique (IASP-213), 37380 Nouzilly, France. Phone: (33) 2 47 42 79 88. Fax: (33) 2 47 42 77 74. E-mail: payot{at}tours.inra.fr.

{triangledown} Published ahead of print on 28 August 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3893-3896, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00616-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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