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Antimicrobial Agents and Chemotherapy, November 2006, p. 3901-3904, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.01506-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Killing of Nosocomial Pathogens by Acid and Acidified Nitrite

Agam Rao,1 Robin L. P. Jump,1 Nicole J. Pultz,2 Michael J. Pultz,2 and Curtis J. Donskey2*

Department of Medicine, University Hospitals of Cleveland, Cleveland, Ohio,1 Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio2

Received 23 November 2005/ Returned for modification 9 March 2006/ Accepted 2 July 2006

Exposure to pH 1 or 2 buffers or acidic gastric contents resulted in the killing of vancomycin-resistant Enterococcus sp., Klebsiella pneumoniae, Staphylococcus aureus, and Candida glabrata but not Clostridium difficile spores. Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels.

* Corresponding author. Mailing address: Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106. Phone: (216) 791-3800, ext. 5103. Fax: (216) 229-8509. E-mail: curtisd123{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3901-3904, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.01506-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nerandzic, M. M., Pultz, M. J., Donskey, C. J. (2009). Examination of Potential Mechanisms To Explain the Association between Proton Pump Inhibitors and Clostridium difficile Infection. Antimicrob. Agents Chemother. 53: 4133-4137 [Abstract] [Full Text]  
  • Sorg, J. A., Sonenshein, A. L. (2008). Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores. J. Bacteriol. 190: 2505-2512 [Abstract] [Full Text]  
  • Jump, R. L. P., Pultz, M. J., Donskey, C. J. (2007). Vegetative Clostridium difficile Survives in Room Air on Moist Surfaces and in Gastric Contents with Reduced Acidity: a Potential Mechanism To Explain the Association between Proton Pump Inhibitors and C. difficile-Associated Diarrhea?. Antimicrob. Agents Chemother. 51: 2883-2887 [Abstract] [Full Text]  


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