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Antimicrobial Agents and Chemotherapy, November 2006, p. 3905-3907, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00522-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Suppression of Gastric Acid Production by Proton Pump Inhibitor Treatment Facilitates Colonization of the Large Intestine by Vancomycin-Resistant Enterococcus spp. and Klebsiella pneumoniae in Clindamycin-Treated Mice{triangledown}

Usha Stiefel,1 Agam Rao,2 Michael J. Pultz,2 Robin L. P. Jump,2 David C. Aron,1 and Curtis J. Donskey1*

Research Service, Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio 44106,1 University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 441062

Received 27 April 2006/ Returned for modification 6 August 2006/ Accepted 17 August 2006

Proton pump inhibitor treatment of clindamycin-treated mice elevated the gastric pH and facilitated the establishment of colonization of the large intestine by vancomycin-resistant Enterococcus spp. (75 to 80%, versus 20 to 25% for saline-treated controls) and Klebsiella pneumoniae (90%, versus 30% for saline-treated controls). These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens.

* Corresponding author. Mailing address: Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106. Phone: (216) 791-3800, ext. 5103. Fax: (216) 229-8509. E-mail: curtisd123{at}yahoo.com.

{triangledown} Published ahead of print on 28 August 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3905-3907, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00522-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nerandzic, M. M., Pultz, M. J., Donskey, C. J. (2009). Examination of Potential Mechanisms To Explain the Association between Proton Pump Inhibitors and Clostridium difficile Infection. Antimicrob. Agents Chemother. 53: 4133-4137 [Abstract] [Full Text]  


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