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Antimicrobial Agents and Chemotherapy, November 2006, p. 3914-3916, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00587-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Effects of Various Media on the Activity of NXL103 (Formerly XRP 2868), a New Oral Streptogramin, against Haemophilus influenzae

Glenn A. Pankuch,1 Dianne Hoellman,1 André Bryskier,2 John Lowther,2 and Peter C. Appelbaum1*

Hershey Medical Center, Hershey, Pennsylvania 17033,1 Novexel S.A., Romainville, France2

Received 12 May 2006/ Returned for modification 25 June 2006/ Accepted 12 July 2006

The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC50 and MIC90 values of 0.5 and 0.5 to 1 µg/ml, respectively, in each medium.

* Corresponding author. Mailing address: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033. Phone: (717) 531-5113. Fax: (717) 531-7953. E-mail: pappelbaum{at}psu.edu.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3914-3916, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00587-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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