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Antimicrobial Agents and Chemotherapy, November 2006, p. 3953-3955, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00915-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Prevalence in the United States of aac(6')-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme{triangledown}

Chi Hye Park,1 Ari Robicsek,2 George A. Jacoby,3 Daniel Sahm,4 and David C. Hooper1*

Massachusetts General Hospital, Boston, Massachusetts,1 Evanston Northwestern Healthcare, Evanston, Illinois,2 Lahey Clinic, Burlington, Massachusetts,3 Focus BioInova, Herndon, Virginia4

Received 24 July 2006/ Returned for modification 13 August 2006/ Accepted 24 August 2006

Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of ≥0.25 µg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% of isolates, and of these, 28% carried the cr variant responsible for low-level ciprofloxacin resistance. aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes.

* Corresponding author. Mailing address: Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114-2696. Phone: (617) 643-3856. Fax: (617) 726-7416. E-mail: dhooper{at}partners.org.

{triangledown} Published ahead of print on 5 September 2006.

Antimicrobial Agents and Chemotherapy, November 2006, p. 3953-3955, Vol. 50, No. 11
0066-4804/06/$08.00+0     doi:10.1128/AAC.00915-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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