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Antimicrobial Agents and Chemotherapy, December 2006, p. 4177-4181, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00619-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Genetic Environment of Acquired bla_ACC-1 ß-Lactamase Gene in Enterobacteriaceae Isolates

Université Paris VI, UPRES EA 2392, UFR de Médecine Pierre et Marie Curie, Paris, France,¹ AP-HP, Hôpital Tenon, Service de Bactériologie, Paris, France,² AP-HP, Hôpital Raymond Poincaré, Laboratoire de Microbiologie, Garches, France,³ Service de Microbiologie, CHU Habib Bourguiba, Sfax, Tunisia,⁴ AP-HP, Hôpital Cochin, Service de Bactériologie, Paris, France⁵

Received 19 May 2006/ Returned for modification 8 July 2006/ Accepted 6 September 2006

We studied the genetic organization of bla_ACC-1 in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.

Published ahead of print on 18 September 2006.

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