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Antimicrobial Agents and Chemotherapy, December 2006, p. 4186-4188, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00494-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of CS-023 (RO4908463), a Novel Parenteral Carbapenem, in Healthy Male Caucasian Volunteers{triangledown}

Takahiro Shibayama,1* Yoko Matsushita,1 Takashi Hirota,1 Toshihiko Ikeda,1 and Shogo Kuwahara2

Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co., Ltd., Shinagawa-ku, Tokyo, Japan,1 Toho University School of Medicine, Ohta-ku, Tokyo, Japan2

Received 21 April 2006/ Returned for modification 10 August 2006/ Accepted 10 September 2006

The CS-023 concentration in plasma after administration by infusion to healthy volunteers at a dose of 700 mg was decreased, with a half-life of 1.7 h, and the cumulative urinary excretion was 59.4% of the dose. The total clearance, renal clearance, and volume of distribution were 8.12 liters/h, 4.14 liters/h, and 17.2 liters, respectively.

* Corresponding author. Mailing address: Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan. Phone: 81-3-3492-3131. Fax: 81-3-5436-8567. E-mail: sibaya{at}sankyo.co.jp.

{triangledown} Published ahead of print on 16 October 2006.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4186-4188, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00494-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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