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Antimicrobial Agents and Chemotherapy, December 2006, p. 4206-4208, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00793-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Inhibition of Toxoplasma gondii by Four New Derivatives of Artemisinin{triangledown}

Lorraine Jones-Brando,1,{dagger}* John D'Angelo,2,{dagger} Gary H. Posner,2 and Robert Yolken1

Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland,1 Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, Baltimore, Maryland2

Received 30 June 2006/ Returned for modification 7 September 2006/ Accepted 2 October 2006

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

* Corresponding author. Mailing address: Stanley Division of Developmental Neurovirology, Dept. of Pediatrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287-4988. Phone: (410) 614-0730. Fax: (410) 955-3723. E-mail: lbrando{at}jhmi.edu.

{triangledown} Published ahead of print on 23 October 2006.

{dagger} These authors contributed equally to this work.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4206-4208, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00793-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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