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Antimicrobial Agents and Chemotherapy, December 2006, p. 4224-4228, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00904-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

qnrA in CTX-M-Producing Escherichia coli Isolates from France{triangledown}

Jean-Philippe Lavigne,1,2 Hélène Marchandin,1,3 Julien Delmas,4,5 Nicole Bouziges,1,2 Evelyne Lecaillon,6 Laurent Cavalie,3 Hélène Jean-Pierre,1,3 Richard Bonnet,4,5 and Albert Sotto1*

Laboratoire Universitaire d'Antibiologie, UFR de Médecine, Avenue Kennedy, 30908 Nîmes Cedex 2, France,1 Laboratoire de Bactériologie, Virologie, Parasitologie, CHU de Nîmes, Groupe Hospitalo-Universitaire de Carémeau, Place du Professeur Robert Debré, 30029 Nîmes Cedex 9, France,2 Laboratoire de Bactériologie, CHU Arnaud de Villeneuve, 371, avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France,3 Laboratoire de Bactériologie, CHU Clermont-Ferrand, 63003 Clermont-Ferrand, France,4 Laboratoire de Bactériologie, Université de Clermont 1, Faculté de médecine, 63001 Clermont-Ferrand, France,5 Service de Biologie Polyvalente, CHG Saint-Jean-Perpignan, 20 Avenue du Languedoc, 66046 Perpignan, France6

Received 22 July 2006/ Returned for modification 23 August 2006/ Accepted 5 September 2006

By PCR, we screened for qnr genes 112 clinical isolates of extended-spectrum ß-lactamase-producing Escherichia coli collected from hospitals in France during 2004. For the first time, 7.7% of CTX-M-producing E. coli isolates presented a plasmid-mediated resistance to quinolones. All strains harbored a qnrA gene located on a sul1-type class 1 integron with similar structure to the In36 integron.

* Corresponding author. Mailing address: Laboratoire Universitaire d'Antibiologie, Faculté de Médecine, CS83021, Avenue Kennedy, 30908 Nîmes Cedex 02, France. Phone: (33) 4 66 68 32 31. Fax: (33) 4 66 68 38 24. E-mail: albert.sotto{at}chu-nimes.fr.

{triangledown} Published ahead of print on 18 September 2006.

Antimicrobial Agents and Chemotherapy, December 2006, p. 4224-4228, Vol. 50, No. 12
0066-4804/06/$08.00+0     doi:10.1128/AAC.00904-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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