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Antimicrobial Agents and Chemotherapy, February 2006, p. 739-743, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.739-743.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Doxycycline Attenuated Pulmonary Fibrosis Induced by Bleomycin in Mice

Masaki Fujita,* Qing Ye, Hiroshi Ouchi, Eiji Harada, Ichiro Inoshima, Kazuyoshi Kuwano, and Yoichi Nakanishi

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Received 21 June 2005/ Returned for modification 20 July 2005/ Accepted 15 November 2005

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

* Corresponding author. Mailing address: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812, Japan. Phone: 81-92-642-5378. Fax: 81-92-642-5389. E-mail: fujita{at}kokyu.med.kyushu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, February 2006, p. 739-743, Vol. 50, No. 2
0066-4804/06/$08.00+0     doi:10.1128/AAC.50.2.739-743.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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